CIRS & MARCoNS Evaluation in Indiana

Chronic inflammation is not just about isolated symptoms. It’s about how the immune system, nervous system, and detoxification pathways respond to ongoing biotoxin exposure over time. At The Functional MDs, our CIRS and MARCoNS evaluation focuses on identifying inflammatory patterns linked to mold or biotoxin exposure and providing phased, physician-led support to restore immune balance, neurological function, and overall resilience.

What Is CIRS & MARCoNS?

Chronic Inflammatory Response Syndrome (CIRS) is a multi-system condition driven by persistent immune dysregulation after exposure to biotoxins, most commonly mold from water-damaged environments. In susceptible individuals, inflammation does not properly resolve, leading to symptoms that affect neurological, hormonal, metabolic, and immune health.
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MARCoNS is a resistant nasal bacterial pattern often associated with CIRS that can further disrupt immune signaling and prolong inflammation. At The Functional MDs, CIRS care focuses on identifying inflammatory triggers and supporting immune regulation through a structured, phased approach.

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Signs You May Benefit From CIRS & MARCoNS Support

CIRS often develops gradually and can be difficult to recognize, especially when symptoms affect multiple systems at once. Many patients seek care after months or years of unexplained illness despite normal standard lab results.

  • Persistent Fatigue or Poor Stress Tolerance
    Ongoing immune activation can disrupt cellular energy production, leading to exhaustion, poor recovery, and symptom flares with physical or emotional stress.
  • Brain Fog or Cognitive Changes
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    Memory issues, difficulty concentrating, or reduced mental clarity may reflect neuroinflammation related to mold or biotoxin exposure.
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  • Neurological or Sensory Symptoms
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    Headaches, dizziness, light sensitivity, or mood changes can occur as inflammation impacts the nervous system.

  • Chronic Sinus or Systemic Inflammatory Symptoms
    Recurrent sinus congestion, joint pain, sleep disruption, or hormonal imbalance may signal unresolved inflammation rather than isolated conditions.
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Our Approach to CIRS & MARCoNS Care

These conditions require clinical precision, restraint, and long-range thinking. We don’t chase lab markers or follow online detox protocols. We evaluate patterns, identify system collapse points, and create a stepwise strategy based on your capacity, labs, and response.

Our approach begins with a detailed intake, exposure history, and testing when clinically appropriate. From there, we build a structured, physician-guided care plan designed to support immune regulation, inflammation resolution, and neuroendocrine recovery.

Your plan may include:

  • Immune-modulating nutrition and therapeutic supplementation
  • Mitochondrial and adrenal support for recovery capacity
  • Targeted antimicrobial strategies for nasal microbiome restoration (when indicated)
  • Gentle detox and drainage strategies personalized to your phase
  • Environmental and exposure reduction guidance
  • Nervous system regulation techniques to reduce hypersensitivity

What to Expect from Your CIRS & MARCoNS Plan

Your CIRS plan begins with an in-depth medical consultation and targeted testing based on your symptom pattern and exposure history. Once your physician identifies contributing inflammatory drivers, a phased support strategy is developed to reduce immune activation and restore system balance. Patients often notice:
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  • Improved mental clarity and reduced brain fog
  • More stable energy levels and stress tolerance
  • Decreased inflammatory and neurological symptoms
  • Improved sleep quality and nervous system regulation
  • Better immune balance and sinus health
  • Enhanced overall resilience and quality of life

Get The Care You Need From The Comfort Of Your Home Through Our Telehealth Options

The Functional MDs offer physician-led functional medicine care through secure telehealth, delivering the same root-cause, personalized approach as in-office care.

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Why Trust Our Team?

Our team brings a wealth of expertise in functional medicine, specializing in uncovering and addressing the underlying factors contributing to health issues.

With a focus on personalized wellness plans, informed by extensive training and experience, our team is dedicated to guiding patients towards sustainable health and vitality.

We’re a team of health fanatics, brought together by one mission; Human Well-Being.

Conditions We Treat at The Functional MDs

"Your body is always speaking: symptoms are just the language. The real question is, are we listening?"

- Dr Singh, MD

The Functional MDs

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