CIRS & MARCoNS Evaluation in Carmel, Indiana

Chronic inflammation is not just about isolated symptoms. It’s about how the immune system, nervous system, and detoxification pathways respond to ongoing biotoxin exposure over time. At The Functional MDs, our CIRS and MARCoNS evaluation focuses on identifying inflammatory patterns linked to mold or biotoxin exposure and providing phased, physician-led support to restore immune balance, neurological function, and overall resilience.

What Is CIRS & MARCoNS?

Chronic Inflammatory Response Syndrome (CIRS) is a multi-system condition driven by persistent immune dysregulation after exposure to biotoxins, most commonly mold from water-damaged environments. In susceptible individuals, inflammation does not properly resolve, leading to symptoms that affect neurological, hormonal, metabolic, and immune health.
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MARCoNS is a resistant nasal bacterial pattern often associated with CIRS that can further disrupt immune signaling and prolong inflammation. At The Functional MDs, CIRS care focuses on identifying inflammatory triggers and supporting immune regulation through a structured, phased approach.

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Signs You May Benefit From CIRS & MARCoNS Support

CIRS often develops gradually and can be difficult to recognize, especially when symptoms affect multiple systems at once. Many patients seek care after months or years of unexplained illness despite normal standard lab results.

  • Persistent Fatigue or Poor Stress Tolerance
    Ongoing immune activation can disrupt cellular energy production, leading to exhaustion, poor recovery, and symptom flares with physical or emotional stress.
  • Brain Fog or Cognitive Changes
    ‍    Memory issues, difficulty concentrating, or reduced mental clarity may reflect neuroinflammation related to mold or biotoxin exposure.
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  • Neurological or Sensory Symptoms
    ‍    Headaches, dizziness, light sensitivity, or mood changes can occur as inflammation impacts the nervous system.

  • Chronic Sinus or Systemic Inflammatory Symptoms
    Recurrent sinus congestion, joint pain, sleep disruption, or hormonal imbalance may signal unresolved inflammation rather than isolated conditions.
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Our MD-Led Functional Approach

At The Functional MDs, CIRS and MARCoNS care is centered on identifying the biological drivers of chronic inflammation rather than masking symptoms. Every patient receives a comprehensive evaluation designed to assess immune activation, neurological involvement, and ongoing inflammatory triggers.

  • Markers of chronic inflammation and immune dysregulation
  • Evaluation for mold-related or biotoxin illness patterns
  • MARCoNS testing when clinically indicated
  • Neuroinflammatory and metabolic stress markers
  • Hormonal and autonomic nervous system balance

What to Expect from Your CIRS & MARCoNS Plan

Your CIRS plan begins with an in-depth medical consultation and targeted testing based on your symptom pattern and exposure history. Once your physician identifies contributing inflammatory drivers, a phased support strategy is developed to reduce immune activation and restore system balance. Patients often notice:
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  • Improved mental clarity and reduced brain fog
  • More stable energy levels and stress tolerance
  • Decreased inflammatory and neurological symptoms
  • Improved sleep quality and nervous system regulation
  • Better immune balance and sinus health
  • Enhanced overall resilience and quality of life

Serving Indiana: Get The Care You Need From The Comfort Of Your Home Through Our Telehealth Options

The Functional MDs offer physician-led functional medicine care through secure telehealth, delivering the same root-cause, personalized approach as in-office care.

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Why Trust Our Team?

Our team brings a wealth of expertise in functional medicine, specializing in uncovering and addressing the underlying factors contributing to health issues.

With a focus on personalized wellness plans, informed by extensive training and experience, our is dedicated to guiding patients towards sustainable health and vitality.

We’re a team of health fanatics🧠💪, brought together by one mission; Human Well-Being.

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Conditions We Treat at The Functional MDs

Hormone Optimization (Thyroid, Adrenal & HRT)

Bioidentical hormone therapy for full-spectrum balance.

Autoimmune Conditions & Chronic Inflammation

Reverse immune imbalance and reduce chronic inflammation.

Gut Health & Food Sensitivities

Heal the gut and uncover reactive foods.

Mold, Heavy Metals, and Environmental Toxins

Treat hidden toxic exposures like mold and heavy metals.

Functional Fertility & Reproductive Health

Root-cause fertility care for women and men.

Chronic Fatigue & Fibromyalgia

Uncover drivers of fatigue and chronic pain.

Cellular Energy, Mitochondria & Detoxification

Strengthen liver function and eliminate internal toxin load.

Mast Cell Activation Syndrome (MCAS)

Support for complex histamine-related symptoms through systems-based, physician-guided care.

Cardiometabolic Health & Cholesterol Optimization

Support heart, blood sugar, and cholesterol health.

Longevity & Healthy Aging

Slow biological aging and support cellular vitality.

Mood & Cognitive Health

Functional approach to anxiety, brain fog, memory, and mood imbalance.

Body Recomposition & Muscle Health

Build muscle and improve body composition.

CIRS & MARCoNS

Evaluation and phased support for chronic inflammatory patterns tied to mold or biotoxin exposure.

Lyme Disease & Tick-Borne Illness

Structured care for persistent symptoms, co-infections, and immune disruption after tick exposure.

Peptide Therapy & Cellular Regeneration

Support cellular repair, recovery, and resilience—under medical guidance.

Post-Viral & Long COVID Recovery

Rebuild energy, clarity, and immune resilience—one system at a time.

Thyroid Health & Hypothyroidism Care

Root-cause thyroid testing and treatment for hypothyroidism, Hashimoto’s, and low T3 conversion.

"Your body is always speaking—symptoms are just the language. The real question is, are we listening?"

- Dr Singh

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