CIRS & MARCoNS in Indiana

Evaluate chronic inflammatory illness at the source — with physician-led insight into immune disruption, neuroinflammation, and mold-related illness.

What We See in Our Patients

Many of our CIRS and mold-related illness patients have seen multiple providers, ruled out major diseases, and are still left with symptoms no one can explain.

  • Brain fog or memory issues
  • Fatigue or post-exertional crashes
  • Mood swings, anxiety, or irritability
  • Light sensitivity, sound sensitivity, or temperature intolerance
  • Hormonal instability
  • Chronic sinus issues or recurring infections
  • Chemical sensitivity or difficulty tolerating medications and supplements

Some have been partially diagnosed or treated for mold illness — but without progress. Others have no formal diagnosis but present with the full clinical picture of CIRS or MARCoNS colonization.

These cases are complex. They require deep clinical context, pattern recognition, and strategic intervention — not protocol-based detox kits.

Systems We Evaluate

CIRS and MARCoNS are multi-system conditions — they don’t follow one pathway or one organ system. That’s why we evaluate each case through a layered, systems-based lens.

Key areas we may assess include:

  • Neuroinflammation and cognitive disruption
  • HPA axis dysregulation and abnormal cortisol rhythms
  • Cytokine signaling and chronic immune activation
  • HLA-DR genetic markers that influence biotoxin clearance
  • MARCoNS colonization in the nasal microbiome and its effect on inflammatory loops
  • Leptin, VEGF, MMP-9, TGF-beta-1, and other inflammatory markers
  • Mitochondrial function and cellular energy output
  • Gut-liver axis and detoxification inefficiencyand cognitive disruption
  • Nervous system hyperreactivity and chemical sensitivity
Testing is ordered selectively and always interpreted in the context of your full clinical history, tolerance, and timeline — never as a protocol-driven checklist.

Our Approach to CIRS & MARCoNS in Indiana

These conditions require clinical precision, restraint, and long-range thinking. We don’t chase lab markers or follow online detox protocols. We evaluate patterns, identify system collapse points, and create a stepwise strategy based on your capacity, labs, and response.

Our approach begins with a detailed intake, exposure history, and testing when clinically appropriate. From there, we build a structured, physician-guided care plan designed to support immune regulation, inflammation resolution, and neuroendocrine recovery.

Your plan may include:

[1]

Immune-modulating nutrition and therapeutic supplementation

[2]

Mitochondrial and adrenal support for recovery capacity

[3]

Targeted antimicrobial strategies for nasal microbiome restoration (when indicated)

[4]

Gentle detox and drainage strategies personalized to your phase

[5]

Environmental and exposure reduction guidance

[6]

Nervous system regulation techniques to reduce hypersensitivity

We treat CIRS and MARCoNS as real, complex, and physiologically layered conditions.
And we guide every step with medical oversight — not guesswork.

[1]
Anti-inflammatory nutrition

[1]
Anti-inflammatory nutrition

[1]
Anti-inflammatory nutrition

[1]
Anti-inflammatory nutrition

[1]
Anti-inflammatory nutrition

Outcomes We Aim For

Our goal isn’t a quick detox. It’s long-term stabilization of the systems impacted by chronic inflammatory response.

Depending on your case, outcomes may include:

1

Improved energy, clarity, and cognitive stamina

2

Fewer flares, crashes, and environmental sensitivities

3

Reduced sinus congestion, skin issues, or histamine symptoms

4

Improved sleep, stress tolerance, and daily resilience

5

Support for hormonal, metabolic, and immune rebalancing

6

A return to functional baseline — guided by a structured care process

These improvements don’t happen overnight. But with the right systems supported, and the right strategy in place, regulation becomes possible.

Suspect mold illness, CIRS, or persistent symptoms no one’s been able to explain?

Frequently Asked Questions

Hormone Optimization

What is CIRS?

What are common symptoms of CIRS?

What is MARCoNS, and how is it related to CIRS?

Do you test for mold or mycotoxins?

Can CIRS be treated with supplements or detox kits?

What kind of testing might be involved?

I’ve seen doctors but still don’t feel better. Can this help?

Is this approach safe for sensitive patients?

How long does it take to feel better?

Is this covered by insurance?

CIRS & MARCoNS Evaluation in Indiana

Chronic inflammation is not just about isolated symptoms. It’s about how the immune system, nervous system, and detoxification pathways respond to ongoing biotoxin exposure over time. At The Functional MDs, our CIRS and MARCoNS evaluation focuses on identifying inflammatory patterns linked to mold or biotoxin exposure and providing phased, physician-led support to restore immune balance, neurological function, and overall resilience.

What Is CIRS & MARCoNS?

Chronic Inflammatory Response Syndrome (CIRS) is a multi-system condition driven by persistent immune dysregulation after exposure to biotoxins, most commonly mold from water-damaged environments. In susceptible individuals, inflammation does not properly resolve, leading to symptoms that affect neurological, hormonal, metabolic, and immune health.

MARCoNS is a resistant nasal bacterial pattern often associated with CIRS that can further disrupt immune signaling and prolong inflammation. At The Functional MDs, CIRS care focuses on identifying inflammatory triggers and supporting immune regulation through a structured, phased approach.

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Signs You May Benefit From CIRS & MARCoNS Support

CIRS often develops gradually and can be difficult to recognize, especially when symptoms affect multiple systems at once. Many patients seek care after months or years of unexplained illness despite normal standard lab results.

  • Persistent Fatigue or Poor Stress Tolerance
    Ongoing immune activation can disrupt cellular energy production, leading to exhaustion, poor recovery, and symptom flares with physical or emotional stress.
  • Brain Fog or Cognitive Changes
    Memory issues, difficulty concentrating, or reduced mental clarity may reflect neuroinflammation related to mold or biotoxin exposure.
  • Neurological or Sensory Symptoms
    Headaches, dizziness, light sensitivity, or mood changes can occur as inflammation impacts the nervous system.

  • Chronic Sinus or Systemic Inflammatory Symptoms
    Recurrent sinus congestion, joint pain, sleep disruption, or hormonal imbalance may signal unresolved inflammation rather than isolated conditions.
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Our Approach to CIRS & MARCoNS Care

These conditions require clinical precision, restraint, and long-range thinking. We don’t chase lab markers or follow online detox protocols. We evaluate patterns, identify system collapse points, and create a stepwise strategy based on your capacity, labs, and response.

Our approach begins with a detailed intake, exposure history, and testing when clinically appropriate. From there, we build a structured, physician-guided care plan designed to support immune regulation, inflammation resolution, and neuroendocrine recovery.

Your plan may include:

  • Immune-modulating nutrition and therapeutic supplementation
  • Mitochondrial and adrenal support for recovery capacity
  • Targeted antimicrobial strategies for nasal microbiome restoration (when indicated)
  • Gentle detox and drainage strategies personalized to your phase
  • Environmental and exposure reduction guidance
  • Nervous system regulation techniques to reduce hypersensitivity

What to Expect from Your CIRS & MARCoNS Plan

Your CIRS plan begins with an in-depth medical consultation and targeted testing based on your symptom pattern and exposure history. Once your physician identifies contributing inflammatory drivers, a phased support strategy is developed to reduce immune activation and restore system balance. Patients often notice:

  • Improved mental clarity and reduced brain fog
  • More stable energy levels and stress tolerance
  • Decreased inflammatory and neurological symptoms
  • Improved sleep quality and nervous system regulation
  • Better immune balance and sinus health
  • Enhanced overall resilience and quality of life

Get The Care You Need From The Comfort Of Your Home Through Our Telehealth Options

The Functional MDs offer physician-led functional medicine care through secure telehealth, delivering the same root-cause, personalized approach as in-office care.

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Why Trust Our Team?

Our team brings a wealth of expertise in functional medicine, specializing in uncovering and addressing the underlying factors contributing to health issues.

With a focus on personalized wellness plans, informed by extensive training and experience, our is dedicated to guiding patients towards sustainable health and vitality.

We’re a team of health fanatics🧠💪, brought together by one mission; Human Well-Being.

Recognized as a Top 3 Holistic Medicine Practitioner in Carmel, Indiana

This distinction reflects our commitment to personalized, root cause focused care grounded in clinical expertise and patient centered medicine.

Conditions We Treat at The Functional MDs

"Your body is always speaking—symptoms are just the language. The real question is, are we listening?"

- Dr Singh

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